I have a fan-less BSD 10.2 Server running MySQL 5.6 I put in for a factory system and which has now been up for just over 300 days since it was built.
It is running along nicely and nobody is complaining but I am starting to get worried I should be doing some preventative maintenance other than the usual resource utilisation and backup checks or even just do a restart just for the hell of it! (Note I am not a *nix guy but the BSD/ZFS system came highly recommended and the build instructions seemed full proof but 300 days seems a lot for a windows guy)
I wont go into specifics but in general what are good things to look out for or check for me and other people in a situation such as this where you could get very complacent?
As long as you are doing all of the usual maintenance tasks (patching, checking logs, monitoring resources etc), there isn't any real need to reboot a *nix/BSD server - certainly not just because you are nervous!