I've been very happy with a layout that is a middle ground between full-size and 60%. Basically you have 18 keys on the right-hand side that can be toggled (using a dedicated button) between arrows + pageup/down + insert etc, and the traditional numpad layout. It is very rare that I need both numpad and arrow keys at the exact same time, so I don't lose any functionality but my hands are more centered towards the front. Even things like Blender that rely heavily on numpad for 3D navigation works well.
My model is old, looks like the most similar current model is the Coolermaster "Masterkeys Pro M" (RGB or white LEDs available):
Another name for this layout is 96 key. I built my own using a YMDK melody 96 layout but before that build I bought the VictSing 96 key which was super cheap (around $50 delivered from the US) and apart from the keycaps having awful legends wasn't too bad.
I'm mulling over doing a custom design with a ISO/US layout so I can kill the function key row but keep both ~` and the escape key. Basically the "Vortex Vibe" but with an ISO layout.
My model is old, looks like the most similar current model is the Coolermaster "Masterkeys Pro M" (RGB or white LEDs available):
https://www.coolermaster.com/us/en-us/catalog/peripheral/key...
Picture of the layout:
https://s3-eu-west-1.amazonaws.com/cdn.coolermaster.com/asse...