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Dose dependent is also worth bearing in mind. Reactive Oxygen Species is also reportedly quite harmful but I guess everything has its place.


> Reactive Oxygen Species is also reportedly quite harmful but I guess everything has its place.

Yes, I think it does. Reactive Oxygen Species (ROS) are generated as part of the metabolic pathway. That is in processes essential for life. Though the details of the biochemistry are beyond me, I recall Cytochrome c oxidase [1] produces H+ used to power ATP generation. Along the way it produces ROS. Of course there are other mechanisms for neutralizing the ROS. The point is ROS probably not something to get too agitated about.

[1] <https://en.wikipedia.org/wiki/Cytochrome_c_oxidase>


When thinking about cell signalling and sensing, I wonder if a group of cells generate ROS to "nuke" a faulty cell, I say nuke because ROS will destroy surrounding healthy cells.

The problem with this theory, is its hard to see it working in anything other than a test tube!

Lets face its not like we can audit each and every cell, its contents and condition in a body is it!?!

Sure we can use some magnetic spin with some chemicals, or radioactice isotopes with others, but the sensing equipment is what holds us back with in vivo studies, so then its back to the patient provided metadata to form an opinion.


LD50 casual reading, not very casual. Carcinogens - who can say with all the confounding factors? Endocrine-disruptors ? people are overly sensitive.. right? </s>

zero trust in big Ag here, truly


Big Ag are likely to also be Big Pharma though, they are chemists, and then depending on their skillset/knowledge/money they specialise in producing certain types of chemicals, thats not to say they couldnt diversify either.

However when is Big Ag is to plants what medicine is to humans? The only problem with farming is they have got good at growing to a certain point in order to maximise yields for human consumption, and this might not always be good for our health. For example, B5 Pantothenic acid, little in pig feed because little causes fat to build up around organs, lots causes fat to deposit under the skin. Supermarkets dont want an inch or two of fat under the skin. So Farmers do what their customers (supermarkets) want, however supermarkets also like to trump out they are meeting customer demand. Is this genuine demand or manufactured consent from the media? If the media, where do they get their opinions from, the editor, or someone else or Govt Legislation? If Govt Legislation, where do they come up with it? Driven by the public or by some other knowledge perhaps military? Or is the above just a bit of everything in a pseudo chaotic fashion, little more than the blind leading the blind?


I worked in computer aided chemistry professionally for almost two years, in California. Both of my managers had PhDs in Chemistry -- they didn't need any help from me on that. I wrote C/C++ code for them. my opinions are my own


So I remember watching a farming program years ago about what could best be described as the hot potato. So chemicals get sprayed on a field of crops and one of the crops would take up more of the chemicals than those around it. It meant that individual plant would be above "safe" or legal levels but because it was impossible to detect which of the plants was the one above allowed levels, they never got tested. I'm also aware of the glyphosate over use issue and how thats been causing health problems. Glyphosate reduces Testosterone levels in rats according to one study and was intergenerational ie the lowered levels were seen in offspring. I think its some sort of management plan for global population levels. Dont know if thats what you are getting at?


for many (maybe even most) compounds there is no safe low-level dose/exposure.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736171/


So too low to stimulate an immune system response based on a typical diet is what this appears to be saying? I do find some Vitamin RDA's to be pernicious!




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