I have heard the name "US Chamber of Commerce" before, and as someone who isn't a politics/government nerd, I always assumed that was some kind of government organization responsible for something...commerce related.

Clicking through to the website and seeing the kind of articles on there makes it pretty obvious that's not the case though, even ignoring the .com domain.

It's the largest lobbying group in the USA. It was created by Taft to fight organized labor. It's a core part of the Republican party, though it will diverge in the interests of capitalism. They denied climate change until 2019.

I think people get that idea due to most cities also having chambers of commerce with lots of influence, sponsoring and hosting events and such.