Why shouldn't we be frustrated by aspects of the natural world? Bad weather, disease, death and so on. Was eliminating smallpox odd because we had no entitlement expect to that?
Those things are about the timeliness - bad weather one day vs another, some people get the disease and others don't, early death verses a longer life. It's about what is reasonable to expect. It might be reasonable to expect good weather on a specific day, or even to live past the age of 50. It's unreasonable to expect to live indefinitely.
Yeah it's probably not 'reasonable' to expect to live on. But sometimes the technical possibilities open up to do something new.
Shaw quote: ‘The reasonable man adapts himself to the world; the unreasonable man persists in trying to adapt the world to himself. Therefore all progress depends on the unreasonable man.’