Other than being immutable, I doubt it. Immutable distros tend to rely on flatpaks to dynamically install new packages. Unfortunately the flatpak codebase is largely unmaintained at this point, and nearly impossible to get changes merged in.

There is already an immutable Fedora with KDE called Kinoite

https://www.fedoraproject.org/atomic-desktops/kinoite/

Reference to Flatpak allegedly not being "actively developed" anymore:

https://news.ycombinator.com/item?id=44068400

Nope: https://github.com/flatpak/flatpak/pulse