Innovation, science and technology. These things make us special as human beings. If there are any human civilizations unwilling to engage in those things, they should be absorbed and assimilated.
While I won't claim he currently has much of interest to say, he definitely explained a lot of important ideas for thinking more clearly to people who would not otherwise have encountered them, even if he didn't invent any of them.
It's late by hundreds of years. It introduces a lot of unnecessary complexity.
The most sophisticated variation of the Wager I've encountered is the Taleb's diatribe against GMO.